Wednesday, 22 September 09:00 – 12:00 Working Group 1 - ESPE Bone and Growth Plate Working Group New Discoveries in Bone and Growth Plate Physiology Moderator(s): Lars Sävendahl, Stockholm, Sweden Gabriele Häusler, Vienna, Austria Estrogen receptors in bone and growth plate physiology Andrei Chagin, Stockholm, Sweden The role of MMPs in bone metabolism – lessons learnt from skeletal dysplasias Outi Mäkitie, Helsinki, Finland The crosstalk between bone and energy metabolisms: the role of adipose tissue Gerald Karsenty, New York, United States The crosstalk between bone and mineral homeostasis: the role of DMP1 and FGF23 Tim Ström, Munich, Germany 10:45 – 11:00 Break Bisphosphonates on the cellular level Terhi Heino, Turku, Finland Bisphosphonates in endocrine practice: to treat or not to treat? Panel discussion Lars Sävendahl, Stockholm, Sweden Annemieke Boot, Groningen, The Netherlands Wolfgang Hogler, Birmingham, United Kingdom 09:00 – 12:00 Working Group 2 - ESPE Disorder of Sex Development Working Group Welcome and introduction Laura Audí, Barcelona, Spain Symposium – European Collaborative Activities Moderator: Christa Flück, Bern, Switzerland The European DSD registry Martina Rodie, Glasgow, United Kingdom E-learning and its application to DSD Sten Drop, Rotterdam, The Netherlands Technological advances in steroid analysis for DSD diagnosis Nils Krone, Birmingham, United Kingdom A new look at androgen insensitivity Paul Martin Holterhus, Kiel, Germany 10:20 – 10:30 Break Round Table - Issues in Management of Testicular DSD Moderator: Claude Migeon, Baltimore, United States Gonadal pathology and tumor risk in relation to clinical characteristics in individuals with 45,X/46,XY mosaicism Martine Cools, Ghent, Belgium Long term results in XY DSD raised as females Michel Polak, Paris, France How ESPE members manage testicular DSD: a survey Nathalie Josso, Paris, France Discussion and debate: towards ESPE DSD Working Group recommendations Open business meeting 09:00 – 12:00 Working Group 3 - ESPE Obesity Club The Development of Adipose Tissue in Children Moderator(s): Antje Körner, Leipzig, Germany Introduction Antje Körner, Leipzig, Germany What is known about adipose tissue biology in children Bessie Spiliotis, Patras, Greece Obtaining (patho)physiological insights from clinical testing Ram Weiss, Jerusalem, Israel Central regulators of peripheral fat Fat vision – the imaging of fat in children Stefan Ehehalt, Tuebingen, Germany New directions in childhood obesity research: how a comprehensive biorepository may allow better prediction of outcomes Matthew A. Sabin, Melbourne, Australia Perspectives of collaborative childhood obesity research in Europe EOC Board 09:00 – 12:00 Working Group 4 - ESPE Paediatric and Adolescent Gynaecology Working Group Adolescent PCOS: New Perspectives (4H - 4H30) Moderator(s): Lourdes Ibáñez, Barcelona, Spain Charles Sultan, Montpellier, France Diagnostic criteria Charles Sultan, Montpellier, France At-risk populations Paul Saenger, New York, United States Role of obesity in PCOS Catherine Pienkowski, Toulouse, France Precocious puberty and PCOS Charles Sultan, Montpellier, France Role of the metabolic syndrome Silva Arslanian, Pittsburgh, United States Treatment of adolescent hyperandrogenism Lourdes Ibáñez, Barcelona, Spain General discussion: toward a consensus? All speakers 09:00 – 12:00 Working Group 5 - ESPE Study Group on Turner Syndrome I. Brain Morphology and Function in Girls with Turner Syndrome Moderator(s): Eva Malecka-Tendera, Katowice, Poland Jesus Argente, Madrid, Spain Influence of X chromosome and hormones on human brain development David H. Skuse, London, United Kingdom Genes, brain and cognition in TS Allan Reiss, Stanford, United States Androgen effects on cognitive functions and QOL in TS Nehama Zuckerman-Levin, Hadera, Israel Psychosocial outcomes in North American adults with Turner Syndrome Carolyn Bondy, Bethesda, United States II. Comments on a Questionnaire on the Care of Girls with TS. Suggestions for Management Panel Discussion: Presentation of the responses to the questionnaire and comments Moderator(s): Catherine Dacou-Voutetakis, Athens, Greece Jean-Claude Carel, Paris, France Items followed by commentators: Use of Vit D, Calcium, Biphoshonates, DEXA Ze’ev Hochberg, Haifa, Israel Cardiovascular system Laura Mazzanti, Bologna, Italy Liver pathology, Intestinal tract Cheri L. Deal, Montreal, Canada Thyroid pathology Daniela Larizza, Pavia, Italy Lipids and glucose metabolism evaluation Theo Sas, Ridderkerk, The Netherlands Estrogen therapy Ensio Norjavaara, Mölndal, Sweden Psychological support Alan Reiss, Stanford, United States 12:00 – 12:45 Lunch Break 12:45 – 13:00 Opening Ceremony 13:00 - 14:00 Plenary Session 1 - Autoimmunity and Diabetes Moderator(s): Moshe Phillip, Petah Tikva, Israel Stanislava Koloušková, Prague, Czech Republic Type 1 diabetes epidemiology and genetics in central Europe Ondřej Cinek, Prague, Czech Republic Endocrine autoimmunity: lessons from autoimmune polyendocrine syndrome type I Olle Kämpe, Uppsala, Sweden 14:00 – 15:30 Coffee Break, Visit to the Posters and Exhibition 15:30 - 17:00 Symposium 1 - "Bridging Clinical Care and Basic Research" - Ovarian Development Moderator(s): Olle Söder, Stockholm, Sweden Sten Drop, Rotterdam, The Netherlands Session Aim: This symposium is part of a series of symposia "Bridging Clinical Care and Basic Science". The aim of the series is to emphasize the impact of patient observation on the understanding of basic biological mechanisms. Each presentation starts with a seminal case presentation, that has led to such development. This symposium is to discuss the pathways involved in ovarian development through gene defects. FOXL2 and downstream events in ovarian development Marc Fellous, Paris, France WnT4 and R-spondin1 signaling in ovarian development Anna Biason-Lauber, Zurich, Switzerland NR5A1 (SF1) and premature ovarian failure Ken McElreavey, Paris, France 15:30 - 17:00 Symposium 2 - Diabetes Immunotherapy Moderator(s): Edith Schober, Vienna, Austria Renata Lorini, Genoa, Italy Session Aim: The aim of the symposium is to summarize the natural history of type 1 diabetes in humans, to highlight the potential targets for immune intervention and to present two ongoing approaches in recent onset type 1 diabetes: anti-CD3 and GAD vaccination. Overview of mechanisms and targets of intervention Christian Boitard, Paris, France Immunomodulation with specific antigens: the case for GAD Johnny Ludvigsson, Linköping, Sweden Anti-CD3 monoclonal antibody therapy for treatment and prevention of Type 1 diabetes Kevan C. Herold, New Haven, United States 15:30 - 17:00 Symposium 3 - IGFs and the Nervous System Moderator(s): Martin Savage, London, United Kingdom Stefano Cianfarani, Rome, Italy Session Aim: The aim is to offer an overview of the role played by IGFs in the development and function of central nervous system, illustrating the potential clinical (diagnostic & therapeutic) implications. Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism Martin Holzenberger, Paris, France IGF-I in neuromuscular diseases: therapeutic implications Antonio Musaró, Rome, Italy IGF-I as a protector of brain and vessel development in preterm infants David Ley, Lund, Sweden 15:30 - 16:30 Meet the Expert 1:1 - Central Diabetes Insipidus Mohamad Maghnie, Genova, Italy This session is interactive and located in a smaller room. Seats are limited and will therefore be allocated on a “first-come-first-served” basis. 15:30 - 16:30 Meet the Expert 2:1 - Long Term Follow-Up of Hashimoto Thyroiditis Marek Niedziela, Poznan, Poland This session is interactive and located in a smaller room. Seats are limited and will therefore be allocated on a “first-come-first-served” basis. 15:30 - 16:30 Meet the Expert 3:1 - Precocious Puberty - When to Start and Stop Treatment Lucia Ghizzoni, Parma, Italy This session is interactive and located in a smaller room. Seats are limited and will therefore be allocated on a “first-come-first-served” basis. 15:30 - 16:30 Meet the Expert 4:1 - Type 2 Diabetes Silva Arslanian, Pittsburgh, United States This session is interactive and located in a smaller room. Seats are limited and will therefore be allocated on a “first-come-first-served” basis. 16:30 – 17:15 Break 17:15 – 18:45 ESPE Satellite Symposium - Sponsored by Ipsen Predicting Response to Growth Promoting Therapy in Children with Short Stature – Tools for Today and Tomorrow? Moderator(s): Rubén Díaz Naderi, Barcelona, Spain Mohamad Maghnie, Genova, Italy Serum biomarkers of therapeutic response Martin Savage, London, United Kingdom The value of growth prediction models Régis Coutant, Angers, France Preliminary results of Epigrow: an epidemiology study in children with ISS Peter Clayton, Manchester, United Kingdom rhGH and rhIGF-1 combination treatment: new clinical data Kurt Midyett, Kansas City, United States Q&A and moderators closing remarks 17:15 – 18:45 ESPE Satellite Symposium - Sponsored by Sandoz Effects of GH Treatment on Muscles and Bone Metabolism Moderator(s): Stephen M Shalet, Manchester, United Kingdom Eckhard Schönau, Köln, Germany The functional muscle-bone unit in diagnosis and therapy Eckhard Schönau, Köln, Germany Effect of GHD and GH therapy on muscle, bone and fracture risk Wolfgang Högler, Birmingham, United Kingdom GH and osetogenesis imperfecta Franco Antoniazzi, Verona, Italy 17:15 – 18:45 ESPE Satellite Symposium - Sponsored by Novo Nordisk Transition from the Paediatric to the Adult Clinic Moderator: Tadej Battelino, Ljubljana, Slovenia Transition of type I patients from the paediatric to the adult clinic Fergus Cameron, Melbourne, Australia Transition of Turner patients from the paediatric to the adult clinic Carolyn Bondy, Bethesda, United States Transition of GHD patients from the paediatric to the adult clinic Peter Kann, Marburg, Germany 18:45 Welcome Reception at Prague Congress Centre